Men above 44 years old, especially those taking prescription medications, were found to be more susceptible to experiencing palpable gynecomastia, a medical condition that causes enlarged man breasts.
Gynecomastia is the presence of an enlargement or excess of the glandular component of the breast. A hormone imbalance primarily causes this medical condition. Certain medications may contain side effects that can cause a hormonal disturbance, which can lead to the development of glandular type gynecomastia.
Statin, Amoxicillin, And Proton Pump Inhibitors Increase Gynecomastia Risk: Prescription Medications
Medications for high cholesterol (statin), bacterial infections (amoxicillin) and gastrointestinal diseases (proton pump inhibitors) are at higher risk of developing gynecomastia.
Case reports in 2018 on “Statin Medications And The Risk Of Gynecomastia1” have suggested an increased risk of gynecomastia with statins, a class of drugs often prescribed to help reduce cholesterol levels in the blood. Medications in the form of proton-pump inhibitors (PPIs) and amoxicillin, commonly used in the treatment of a wide variety of bacterial infections, have also been shown to cause gynecomastia in users2.
- Skeldon, S. C., Carleton, B., Brophy, J. M., Sodhi, M., & Etminan, M. (2018). Statin Medications And The Risk Of Gynecomastia. Clinical Endocrinology, 89(4), 470-473. doi.org/10.1111/cen.13794 https://onlinelibrary.wiley.com/doi/abs/10.1111/cen.13794
- He, B., Carleton, B., & Etminan, M. (2019). Risk Of Gynecomastia With Users Of Proton Pump Inhibitors. Pharmacotherapy: The Journal Of Human Pharmacology And Drug Therapy, 39(5), 614-618. doi.org/10.1002/phar.2245 https://accpjournals.onlinelibrary.wiley.com/doi/abs/10.1002/phar.2245