Gynecomastia Forum, Doctor and Surgery Resources

Gynecomastia Acceptance => Acceptance => Topic started by: chestyoldman on August 19, 2017, 10:47:36 AM

Title: Effecst of testosterone replacement therapy on gynecomastia
Post by: chestyoldman on August 19, 2017, 10:47:36 AM
[font="Open Sans", sans-serif]Are any of you guys with gynecomastia also on testosterone replacement therapy, especially by injection? If so, I would like to know what you have experienced. Specifically, I'm wondering about the effects TRT might have on my gynecomastia.[/font][/color]
[font="Open Sans", sans-serif]I have started testosterone injections and I had my first of 4 last Tuesday 8/15. After the 4th injection I will go back to my urologist to check my T level. [/font][/color][font="Open Sans", sans-serif]In doing my reading about the benefits and side effects I repeatedly saw that TRT can cause enlarged breasts. Since I already have "enlarged breasts" (AKA gynecomastia) does this mean I should [/font][/color][font="Open Sans", sans-serif]expect[/font][/color][/b][font="Open Sans", sans-serif] them to get larger, or is this just a possibility? How common is it for men on TRT to report breast enlargement? Of course, like so many other things, I understand that "my mileage may vary" and it might not affect me at all. I would just like to start preparing myself and my wife for the possibility that my breasts will get larger and I may need to buy bigger bras.[/font][/color]
Title: Re: Effecst of testosterone replacement therapy on gynecomastia
Post by: aboywithgirls on August 19, 2017, 11:36:42 AM
I've never had any TRY. So I can't tell you much. All I can say is that the endocrine system is very complex juggling act. I have had my boobs since puberty. They were already well developed DDs. After a thyroidectomy I went to an H cup. That was over a 5 year span. The boutiques that I shopped at couldn't believe that I was growing so much so fast at my age. They have had other men who needed support as well but they were B's and Cs.
Title: Re: Effecst of testosterone replacement therapy on gynecomastia
Post by: Anon E Mouse on August 20, 2017, 02:16:56 AM
The short answer is yes, Testosterone replacement can cause Gynecomastia. The mechanism is called Aromatization. The Aromatase enzyme found in our bodies converts excess Testosterone into Estrogen.
So, low Testosterone and the body "sees" more of the natural Estrogen in our body and often reacts by developing breast tissue. Replace the lost Testosterone and the Aromatase Enzyme converts some of it to Estrogen, and the body again reacts by developing breast tissue. Everyone's different and may or may not react the same way.
Tamoxifen is sometimes used to prevent the conversion, but the risks include blood clots & strokes. Aromatase inhibitors have other risks such as heart problems & Osteoporosis. In short, sometimes the cure can be worse than the disease.
Many of us have concluded that merely growing breasts is not sufficient reason to risk something worse. Growing breasts won't kill us, but in some cases the cure for it might.
Title: Re: Effecst of testosterone replacement therapy on gynecomastia
Post by: chestyoldman on August 20, 2017, 09:45:06 AM
Thanks for your replies, guys. I'm not concerned that my breasts might get bigger. If the TRT makes me feel better and helps me get erections and horniness back I would consider that a great trade! I'm just trying to sort out the other results I might see and wondering if I might be more susceptible to breast growth since I already had gynecomastia when I started the TRT. My wife had a horrible time adjusting to me having breasts and deciding to wear bras, so I'm trying to prepare her in advance if both may be getting bigger. 
Title: Re: Effecst of testosterone replacement therapy on gynecomastia
Post by: aboywithgirls on August 20, 2017, 11:06:20 AM
Absolutely. Get her prepared. When I started to grow further after my thyroidectomy, it wasn't a big deal but when I was fitted, I was wearing a 38DDD, same size as my wife. Even after weight loss this year. I was refitted for the same bra and I'm now a 36H. We've made adjustments now that I'm bigger, she knows I need to wear. For me it's probably easier because I already had breasts when we met and wore a bra fulltime. 
They're only breasts! Everyone has them and some just need a little support. 
Title: Re: Effecst of testosterone replacement therapy on gynecomastia
Post by: chestyoldman on August 21, 2017, 09:11:32 AM
Thanks, aboywithgirls! I love what you said. "They're only breasts! Everyone has them and some just need a little support." Unfortunately, my wife only sees the bra as belonging to women and not just as a means of supporting breasts. She has gotten better, though. I just want to find out as much as possible about the effects of this new med. Forewarned is forearmed.
Title: Re: Effecst of testosterone replacement therapy on gynecomastia
Post by: Alchemist on September 13, 2017, 05:17:08 PM
I've been on TRT (with regular level tests) for 17 years and had no effects at all on my breasts.  I started feeling a lot better within days.  It wasn't until after I started the right nutrients that my atrophied muscles rebuilt and my hematocrit started climbing through the roof.  I had to reduce p-5-p to get the hematocrit back to normal.

And you know, if they grow a little, who cares.  They shrank down a cup or so with removal of more edema and subcutaneous fat, which the doctor said DON'T LOSE IT. I didn't on purpose and that can get out of control.  I have plenty of more important things to deal with.  Good luck.  I'm seeing a urologist and for now he is managing the testosterone and other things.    And believe me, it can lead to some conundrums.  Some nutrients that help liver problems appear to cause problems with the prostate, or maybe not but lots of combinations are not clear.  Good luck.
Title: Re: Effecst of testosterone replacement therapy on gynecomastia
Post by: dr.moe on September 25, 2017, 09:57:30 PM
I've been on TRT for a couple of years, and it's really hard to tell if it has affected my breasts or not. I suspect so, since my T-level hasn't budged (still sub-100) while my estrogen level has risen. I think my breasts have stopped growing, but lately they've started feeling tender again (with my nipples feeling a bit puffy). As was noted, when my doctor told me the potential side-effects of aromatase inhibitors, I said 'no way'.  If my next blood test shows my T-level is still low, my doc and I have agreed to back off the TRT for a while and see if that somehow brings my E-level back down.  On the other hand, I may end up with another growth spurt.

They're only breasts.

Title: Re: Effecst of testosterone replacement therapy on gynecomastia
Post by: bustymale on October 17, 2017, 05:59:01 PM
My breasts developed at puberty and I have never undergone any testosterone replacement therapy.  If I did HRT it would probably not be testosterone I would take LOL.
Title: Re: Effecst of testosterone replacement therapy on gynecomastia
Post by: dr.moe on October 21, 2017, 11:24:25 AM
Every single human body is different, including how we react to hormone supplementation. You may have to go through a 'trial and error' phase with a doctor to find out if TRT has any impact on your gyno. Odds are no, but there are strange cases (like mine) that show you never can tell.
Title: Re: Effecst of testosterone replacement therapy on gynecomastia
Post by: chestyoldman on October 22, 2017, 11:12:08 AM
I had my first appointment with my urologist last Thursday after undergoing 4 TRT injections 2 weeks apart. My initial T level was 335 (scale 300-800) and now it is 696.84. He wants me to continue the injections 2 weeks apart and return every 6 months to monitor me. He told me that of the 100's of men he sees who are on TRT he has had a small few who have reported breast growth. Apparently it's a possibility that mine will get larger, but it doesn't sound like it's a foregone conclusion that they will. Whatever. I'm OK either way, but it will be cheaper if I don't have to replace my bra wardrobe all at once!
Title: Re: Effecst of testosterone replacement therapy on gynecomastia
Post by: mgr on October 29, 2017, 02:23:04 PM
Agreed, everyone is different. I have been on TRT since May and am still attempting to get the dosage correct.  Without TRT, my T total T levels are 7 and my free are undectable. I use Androgel because my doctor and I do not want the surge level you get with injections.  After attempting a few different dosages as my T levels increased, we had to back down because it was impacting me mentally and pyhsically.  Once I got into the mid 400’s on total, my nipples began to itch like crazy and I had breast growth.  I just had my blood drawn yesterday and will see in about a week what the new levels are.  My body appears to operate best at the low end of normal or just below. We will see.
Title: Re: Effecst of testosterone replacement therapy on gynecomastia
Post by: Cisco on October 30, 2017, 03:22:05 PM
Agreed, everyone is different. I have been on TRT since May and am still attempting to get the dosage correct.  Without TRT, my T total T levels are 7 and my free are undectable. I use Androgel because my doctor and I do not want the surge level you get with injections.  After attempting a few different dosages as my T levels increased, we had to back down because it was impacting me mentally and pyhsically.  Once I got into the mid 400’s on total, my nipples began to itch like crazy and I had breast growth.  I just had my blood drawn yesterday and will see in about a week what the new levels are.  My body appears to operate best at the low end of normal or just below. We will see.

A quick question did you have any pain or discomfort in your breast while they were growing?
Title: Re: Effecst of testosterone replacement therapy on gynecomastia
Post by: dr.moe on October 30, 2017, 04:03:23 PM
A quick question did you have any pain or discomfort in your breast while they were growing?

I can't speak for others, but for me - yes.  Definitely yes.  Feeling 'full' - if that's easy to describe, which it's not.  Nipples tender to the touch - so sensitive at times that wearing a t-shirt was like rubbing my chest with 40-grit sandpaper.  (BTW - hint - pique cotton fabric is really rough on nipples!) The breast tissue beneath my nipples was a little sensitive to pressure as well.  A little bit like how when you have swelling with a bruise, it is touch-tender.
 
My latest tests show T-level is back down - sub-100, and E remains stubbornly high.  And my breasts and nipples have that full, sensitive sensation again, which means I'm probably undergoing another (hopefully minor) growth spurt.
 
And I just got a couple of nice fitting bras, too :(
Title: Re: Effecst of testosterone replacement therapy on gynecomastia
Post by: Cisco on November 03, 2017, 04:07:55 PM
A quick question did you have any pain or discomfort in your breast while they were growing?

I can't speak for others, but for me - yes.  Definitely yes.  Feeling 'full' - if that's easy to describe, which it's not.  Nipples tender to the touch - so sensitive at times that wearing a t-shirt was like rubbing my chest with 40-grit sandpaper.  (BTW - hint - pique cotton fabric is really rough on nipples!) The breast tissue beneath my nipples was a little sensitive to pressure as well.  A little bit like how when you have swelling with a bruise, it is touch-tender.
 
My latest tests show T-level is back down - sub-100, and E remains stubbornly high.  And my breasts and nipples have that full, sensitive sensation again, which means I'm probably undergoing another (hopefully minor) growth spurt.
 
And I just got a couple of nice fitting bras, too :(

I know that feeling of "fullness" in my breasts.  I've experienced it too from time to time.
Title: Re: Effecst of testosterone replacement therapy on gynecomastia
Post by: maxx on March 29, 2018, 05:50:50 PM
I thought I would reply, even though this is an aging thread. 
I have been on TRT for about 18months now. I was on it in the past, but I was using Androgel and found it to be to much of a PITA to bother with. 
This time I am doing weekly injections, myself. No big deal. Much more effective than the gel, in my experience!
My situation is a little different in that I also take Spironolactone for PA. That is was caused my hypogonadism. It blocks testosterone receptors, which triggered my Gyno about 11 years ago.
Anyway, me endo was not checking my estrogen, until I asked him to. My T was in the mid upper range for a male, but my Estrogen was also in the lower female range.
I ended up having my hair falling out because of high DHT, so I am also taking finasteride.
I have had slight growth, but nothing really explosive. According to measuring guide, I am a 42D, but I am also way over weight. If I were to lose weight, I would no longer look like a fat guy with moobs, but rather full on female breasts. My big gut masks how large my breasts are, to some degree. 
As suggested on this forum, I did ask my Endo about a low dose of estrogen, rather than the T. He didnt want to do that. I was mostly taking the T for osteopenia. But, it has definitely helped me with energy and strength.
Like what has been said before, everyone is different. If you are taking it, by now you probably can share your own experience on the side effects.
As large as my breast are, I still do not wear a bra. I have purchased a few, but never really found anything comfortable. I actually got mad one day and tossed them in the trash. Guess I am still fighting the idea more than I realized.
I wish i didn't feel like I have to hide, because I do not hate them. They have become an interesting experience. I am married, and my wife understands my situation. She is not comfortable with the bra idea, yet. But, neither am I. I am not in that much pain, so it is really not an issue. Toughest part is occasionally snagging a nipple on a box or something when I am not paying attention. Even with a shirt on, it can hurt like crazy.
Anyway, I am wandering all over, so I will end it here. Wondering how things turned out for you with the TRT?
 
Title: Re: Effecst of testosterone replacement therapy on gynecomastia
Post by: SideSet on March 29, 2018, 06:26:25 PM
 Chesty, since you already have gynecomastia, I am guessing you would be prone to for the breast development while on the testosterone replacement program.  My bet is you go up a cup size.
Title: Re: Effecst of testosterone replacement therapy on gynecomastia
Post by: Jaku on March 30, 2018, 11:21:32 AM
Chesty, I have had TRT off and on for about 6 years.  I started with injections.  My breasts did enlarge during this time.  However, there is a medication that can be prescribed to help prevent this.  Of bigger concern to me at the time, was that because of the immediate spark or jump in the T level, there was intense aggressiveness, and almost uncontrollable libido.  There are a couple ways you can do the injections, once every two weeks (big dose) or once a week (smaller dose).  The latter was better for me.  I stopped TRT when I had surgery last year, but have since started up again with the rub on gel.  This has been the best for me.  Every one is different and I am just telling you my experience.  If it helps, I am now 64.
Title: Re: Effecst of testosterone replacement therapy on gynecomastia
Post by: chestyoldman on March 30, 2018, 02:27:18 PM
I thought I would update my progress with TRT. My doc put me on 1 injection every 2 weeks, and after being on it for about 6 weeks he did a blood test and my T level had almost doubled. I'm due for a blood draw next week and an appointment with him the following week for a 6-month status check. Since I am insulin-dependent diabetic and give myself 5 or 6 shots every day I decided to do the injections myself. I must say that the size of the needle for the T can be daunting, especially since I have skinny thighs! I'm surprised that big ol' needle doesn't stick in my thigh bone! I feel a lot more energetic and my sexual desire and ability to get and maintain erections have improved, and so far I haven't noticed any change in the size of my breasts. So far I'm very satisfied with my results.
Title: Re: Effecst of testosterone replacement therapy on gynecomastia
Post by: Epic Adventurer on March 31, 2018, 06:03:10 AM
. I must say that the size of the needle for the T can be daunting, especially since I have skinny thighs! I'm surprised that big ol' needle doesn't stick in my thigh bone!

You can draw the T with a 20 gauge needle.  Suck in a little air, then transfer to a smaller gauge for the injection.
Title: Re: Effecst of testosterone replacement therapy on gynecomastia
Post by: chestyoldman on March 31, 2018, 07:15:08 AM
Thank you for the suggestion, Epic Adventurer. My doctor's nurse taught me to draw with an 18 gauge needle and inject with a 22 gauge needle. It's still so much longer and bigger than my ultra-fine short insulin needles that it seems like I'm injecting with a 16-penny nail by comparison!
Title: Re: Effecst of testosterone replacement therapy on gynecomastia
Post by: maxx on March 31, 2018, 09:46:06 AM
I found that injecting T after you shower is less painful. Although, I never really found it all that difficult to tolerate. I did my own shots from day one. 
I moved away from the longer 21 gauge 1" needles and went to 25 Gauge 5/8". It takes a bit to draw in, but i think it does much less damage to the muscle. I didn't move to smaller needle for the pain, but rather to avoid muscle damage over long term use. I am most likely doing injection more into fat than muscle. Whatever...my blood work is stable. So it is working for me.
I too am on insulin, but I was on T shots before i started insulin. I laughed at the insulin needle. It is like a mosquito stinger. 90% of the time I cant even feel it at all.
I do my T injections weekly. I prefer that needle to rubbing gel all over myself and then worrying about it getting on my wife. Plus, the gel it is a huge ripoff in price. Test Cyp is getting absorbed, period. The gel was not consistent, in my opinion. 
Many people are so afraid of needles. It is so much better to take on my system to inject Lantus than it was to take Metformin pills. Also, I would inject the T everyday over using Androgel again. 
All just my experiences, so YMMV, of course.
Title: Re: Effecst of testosterone replacement therapy on gynecomastia
Post by: hammer on March 31, 2018, 11:42:54 AM
It sounds like injecting T has really improved over the years! When I was doing it back in 1995 the needle I had was long and big, like the the 16 penny nail someone else mentioned! As a insulin depended diabetic I'm not afraid of needles, but that was one big needle in the butt every two weeks and I ended up with side effects from it as well!

Shortly after stopping the HRT I had a heart attack, but the doctors never could figure out what was wrong and I never did have any problems since then! I was 37 when I had it and I'm 60 now. I figure it had something to do with the HRT.
Title: Re: Effecst of testosterone replacement therapy on gynecomastia
Post by: Alchemist on April 10, 2018, 12:35:15 AM
I thought I would update my progress with TRT. My doc put me on 1 injection every 2 weeks, and after being on it for about 6 weeks he did a blood test and my T level had almost doubled. I'm due for a blood draw next week and an appointment with him the following week for a 6-month status check. Since I am insulin-dependent diabetic and give myself 5 or 6 shots every day I decided to do the injections myself. I must say that the size of the needle for the T can be daunting, especially since I have skinny thighs! I'm surprised that big ol' needle doesn't stick in my thigh bone! I feel a lot more energetic and my sexual desire and ability to get and maintain erections have improved, and so far I haven't noticed any change in the size of my breasts. So far I'm very satisfied with my results.

I use injections also.  I draw the injection with a 19 gauge needle.  I inject with a 24 or 25 gauge 1" needle.  It isn't anywhere near as intimidating as an 18 or 19 gauge.  I find I do much better, much more even with weekly injections.  10 days is about max and I have been feeling it for a couple days before. I have been using TRT for 18 years now and haven't had a breast size change except for gain/losing weight or edema.
Title: Re: Effecst of testosterone replacement therapy on gynecomastia
Post by: Mr.Joules on October 04, 2018, 12:16:31 PM
For you guys on TRT.

Nr.1 - Use arimidex to lower you estrogen. No need to get gyno just because your on trt.. 

Nr.2 - Inject lowdose subq ED or eod instead of 1 dose ew IM. That lowers you estro ALOT. Subq is just as effective but gives less estro. Backload a insulin needle and shoot 10-20iu.
Title: Re: Effecst of testosterone replacement therapy on gynecomastia
Post by: Alchemist on October 08, 2018, 01:10:28 AM
Thank you for the suggestion, Epic Adventurer. My doctor's nurse taught me to draw with an 18 gauge needle and inject with a 22 gauge needle. It's still so much longer and bigger than my ultra-fine short insulin needles that it seems like I'm injecting with a 16-penny nail by comparison!

Hi Chestyoldman,
I draw with a 19  gauge and inject with a 24 or 25 gauge.  Even 24 gauge is big compared to 30 or 31 gauge short needle.   I've been on TRT for 18 years and it has had no effect at all on gynecomastia for me.